The retinal pigment hookah parts epithelium (RPE) is the primary site of injury in non-neovascular age-related macular degeneration or dry AMD.Polymorphisms in genes that regulate complement activation and cholesterol metabolism are strongly associated with AMD, but the biology underlying disease-associated variants is not well understood.Here, we
In multicellular organisms, cells must continuously exchange messages with the right meaning, intensity, and duration.Most of these messages are delivered through cognate interactions between membrane and secretory proteins.Their conformational maturation is assisted by a vast Belts array of chaperones and enzymes, ensuring the fidelity of intercel
Oral mucosa and salivary gland are composed of complex and dynamic networks of extracellular matrix, multiple cell types, vasculature, and various biochemical agents.Two-dimensional (2D) cell Belts culture is commonly used in testing new drugs and experimental therapies.However, 2D cell culture cannot fully replicate the architecture, physiological
The endothelial cytoskeleton is a barrier for leukocyte transendothelial migration (TEM).Mononuclear and polymorphonuclear leukocytes generate gaps of similar micron-scale size when squeezing through inflamed endothelial barriers in vitro and in vivo.To elucidate how leukocytes squeeze through these barriers, we co-tracked the endothelial actin fil
In the city Jackets of Bobo-Dioulasso in Burkina Faso, Anopheles arabiensis has superseded Anopheles gambiae s.s.as the major malaria vector and the larvae are found in highly polluted habitats normally considered unsuitable for Anopheles mosquitoes.Here we show that An.gambiae s.l.adults emerging from a highly polluted site in the city centre (Dio